I can't think of a way to use the word predilection that doesn't make my skin crawl. In fact, I can't think of a time that anyone has used it in recent memory.

This all started when one of my students in Germany wanted another word to say she prefers something. I said predilection and then realized what I had done as soon as they started making sentences with it in their heavy German accents.
"I have a predilection for places with lots of people."
"I have a predilection for large dogs."
"I have a predicletion for anything covered in mayonnaise."

This word has no right being used in any context outside of talking about a serial killer or rapist. It was towards the end of class and I was anxious to leave, so I didn't try to explain this to them. So there are about 10 Germans in the Berlin area, who when practicing English with a passing tourist probably get a lot of blank and nervous stares.

I racked my brain, trying to think of a way to use the word that wouldn't bring about Silence of the Lambs related connotations.
Like this. If you're in the candy aisle with a friend looking for what you're going to sneak into the theater and he asks you what kind of candy bar you like, say "I have a predilection towards snicker bars," and see if he doesn't leave a seat between the two of you during the film.
He'll probably immediately envision you rubbing a half-melted snickers around your nipples and mouth while you strut around naked and purse your lips in front of the mirror.